Journal article
Analysis of the liver lipidome reveals insights into the protective effect of exercise on high-fat diet-induced hepatosteatosis in mice
AB Jordy, MJ Kraakman, T Gardner, E Estevez, HL Kammoun, JM Weir, B Kiens, PJ Meikle, MA Febbraio, DC Henstridge
American Journal of Physiology Endocrinology and Metabolism | AMER PHYSIOLOGICAL SOC | Published : 2015
Abstract
The accumulation of lipid at ectopic sites, including the skeletal muscle and liver, is a common consequence of obesity and is associated with tissuespecific and whole body insulin resistance. Exercise is well known to improve insulin resistance by mechanisms not completely understood. We performed lipidomic profiling via mass spectrometry in liver and skeletal muscle samples from exercise-trained mice to decipher the lipid changes associated with exercise-induced improvements in whole body glucose metabolism. Obesity and insulin resistance were induced in C57BL/6J mice by high-fat feeding for 4 wk. Mice then underwent an exercise training program (treadmill running) 5 days/wk (Ex) for 4 wk ..
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Awarded by National Health and Medical Research Council of Australia (NHMRC)
Funding Acknowledgements
This study was supported by grants from the National Health and Medical Research Council of Australia (NHMRC; Project Grant 1004441 to M. A. Febbraio) and the Victorian Government Operational Infrastructure Support Program. D. C. Henstridge is supported by a National Heart Foundation Biomedical Postdoctoral Fellowship and Australian Diabetes Society Skip Martin Fellowship. A. B. Jordy is supported by the Augustinus Foundation and the Lundbeck Foundation. B. Kiens is supported by The Danish Council for Independent Research and a UNIK initiative grant. M. A. Febbraio is a Senior Principal Research Fellow of the NHMRC. P. J. Meikle is a Senior Research Fellow of the NHMRC.